According to Matt Maiocco of CSNBayArea.com, center Daniel Kilgore suffered a fractured left leg in Sunday nights loss to the Broncos.
Kilgore is likely to miss the remainder of the season.
“It was upper ankle,” 49ers coach Jim Harbaugh said. “Looks like it might be a break.”
Kilgore was fitted with an air cast immediately after the game.
Said quarterback Colin Kaepernick, “It’s always tragic to lose a player. I don’t know exactly what it is right now. Hopefully, it’s not something that is season-ending.”