The San Francisco 49ers are set to lose their nastiest offensive lineman.
Adam Schefter is reporting that guard, Mike Iupati will sign with the division rival — Arizona Cardinals.
49ers free-agent G Mike Iupati has told people he plans to sign with the Arizona Cardinals, per sources. Iupati vs. SF DT Darnell Dockett.
— Adam Schefter (@AdamSchefter) March 9, 2015
Iupati has spent his entire five-year career with the San Francisco 49ers.