NFL Week 1 is finally underway to bless our eyes with exciting games and rivalries. Trey Lance and the 49ers will host Justin Fields and the Bears in Week 1 of the NFL schedule, pitting two of the league’s most promising rookie quarterbacks against one another.
Both players want to get their sophomore campaigns off to a strong start after disappointing rookie campaigns. One of the biggest NFL spreads of the day is a 7-point favorite for the Niners in the most recent Week 1 NFL odds at Caesars Sportsbook.
Whereas Washington, trying to win its debut game as the Commanders, faces Trevor Lawrence and the Jaguars as three-point underdogs. With so little information available, Week 1 NFL choices may be more difficult to make than any other week. Therefore, having reliable NFL betting tips is undoubtedly helpful.
Below are all of the Week 1 NFL predictions, odds, picks, line, spreads, schedule, tv channel, and live stream.
Top Week 1 NFL Picks and Predictions
Check out NFL lines computer model’s NFL predictions and betting tips before placing any Week 1 NFL picks or NFL parlays. Since its start, the model, which simulates every NFL game 10,000 times, has earned over $7,500 for $100 players on the best NFL picks.
The model has a remarkable 138-97 record on top-rated NFL picks going into the 2022 season, dating back to the 2017 campaign. Amazingly, since Week 15 of the previous season, it hasn’t dropped a top-rated pick. The model also beat more than 94% of CBS Sports Football Pick’em players four times over the course of the last six years, placing in the top 10 on NFL Pick Watch for straight-up NFL picks.
Anyone who has followed it has come a long way. The model has now set five assured NFL Week 1 best bets. If you were to properly parlay its selections, you could expect a hefty payout of about 25-1. The model’s Week 1 NFL predictions are exclusively available at SportsLine.
The Indianapolis Colts are strong favorites to cover as eight-point road underdogs against the Houston Texans, according to the model, which simulates every game 10,000 times. Since Andrew Luck shocked the NFL in 2019, the Colts’ offense has been hindered by quarterback performance.
Indianapolis believes that in veteran Matt Ryan, whom it acquired from the Falcons in the offseason, it has found its finest option to date. In his first game, Ryan should face a Texans team that finished 27th in scoring defense the previous season.
According to the model, Ryan will have a productive day of 21 of 31 passing for about 250 yards and two touchdowns. Jonathan Taylor, a running back, effortlessly surpasses 100 yards on the ground. The Colts are a good option for your Week 1 NFL parlays since they score 29 points and cover in nearly 60% of scenarios.
Week 1 NFL odds, lines, spreads
Thursday, Sept. 8
Rams at Bills (+2.5, 52)
Featured Game – Los Angeles Rams vs. Buffalo Bills
| Moneyline | Spread | Total |
LAR | +115 | +2.5 -110 | o53 -110 |
BUF | -135 | -2.5 -110 | u53 -110 |
Sunday, Sept. 11
Ravens at Jets (+7, 44.5)
Featured Game – New York Jets vs. Baltimore Ravens
| Moneyline | Spread | Total |
NYJ | +260 | +7 -115 | o44.5 -110 |
BAL | -335 | -7 -105 | u44.5 -110 |
Browns at Panthers (-1.5, 41.5)
Featured Game – Carolina Panthers vs. Cleveland Browns
| Moneyline | Spread | Total |
CAR | -135 | -2 -110 | o41.5 -110 |
CLE | +115 | +2 -110 | u41.5 -110 |
Colts at Texans (+8, 44)
Featured Game – Houston Texans vs. Indianapolis Colts
| Moneyline | Spread | Total |
HOU | +300 | +8 -110 | o44 -110 |
IND | -385 | -8 -110 | u44 -110 |
Jaguars at Commanders (-3. 44)
Featured Game – Washington Commanders vs. Jacksonville Jaguars
| Moneyline | Spread | Total |
WAS | -165 | -3 -110 | o44 -110 |
JAC | +140 | +3 -110 | u44 -110 |
Patriots at Dolphins (-2.5, 45)
Featured Game – Miami Dolphins vs. New England Patriots
| Moneyline | Spread | Total |
MIA | -165 | -3 -110 | o45.5 -110 |
NE | +140 | +3 -110 | u45.5 -110 |
Saints at Falcons (+5.5, 42.5)
Featured Game – Atlanta Falcons vs. New Orleans Saints
| Moneyline | Spread | Total |
ATL | +185 | +5.5 -110 | o42.5 -110 |
NO | -225 | -5.5 -110 | u42.5 -110 |
Eagles at Lions (+4, 48.5)
Featured Game – Detroit Lions vs. Philadelphia Eagles
| Moneyline | Spread | Total |
DET | +170 | +4 -110 | o48.5 -110 |
PHI | -205 | -4 -110 | u48.5 -110 |
Steelers at Bengals (-6.5, 44.5)
Featured Game – Cincinnati Bengals vs. Pittsburgh Steelers
| Moneyline | Spread | Total |
CIN | -278 | -6.5 -110 | o44.5 -110 |
PIT | +222 | +6.5 -110 | u44.5 -110 |
49ers at Bears (+7, 42)
Featured Game – Chicago Bears vs. San Francisco 49ers
| Moneyline | Spread | Total |
CHI | +240 | +7 -110 | o41.5 -110 |
SF | -305 | -7 -110 | u41.5 -110 |
Packers at Vikings (+2, 48)
Featured Game – Minnesota Vikings vs. Green Bay Packers
| Moneyline | Spread | Total |
MIN | +110 | +2 -110 | o48 -110 |
GB | -130 | -2 -110 | u48 -110 |
Chiefs at Cardinals (+3.5, 53)
Featured Game – Arizona Cardinals vs. Kansas City Chiefs
| Moneyline | Spread | Total |
ARI | +158 | +3.5 -110 | o54 -110 |
KC | -190 | -3.5 -110 | u54 -110 |
Raiders at Chargers (-3.5, 52)
Featured Game – Los Angeles Chargers vs. Las Vegas Raiders
| Moneyline | Spread | Total |
LAC | -178 | -3.5 -120 | o52 -110 |
LV | +150 | +3.5 +100 | u52 -110 |
Giants at Titans (-5.5, 44)
Featured Game – Tennessee Titans vs. New York Giants
| Moneyline | Spread | Total |
TEN | -250 | -5.5 -110 | o43.5 -110 |
NYG | +205 | +5.5 -110 | u43.5 -110 |
Buccaneers at Cowboys (+1.5, 50)
Featured Game – Dallas Cowboys vs. Tampa Bay Buccaneers
| Moneyline | Spread | Total |
DAL | +100 | +1.5 -110 | o50 -110 |
TB | -120 | -1.5 -110 | u50 -110 |
Monday, Sept. 12
Broncos at Seahawks (+6, 41.5)
Featured Game – Seattle Seahawks vs. Denver Broncos
| Moneyline | Spread | Total |
SEA | +210 | +6.5 -110 | o42 -110 |
DEN | -260 | -6.5 -110 | u42 -110 |
Schedule and TV Channel
Friday, September 9, 2022
MATCHUP | TIME | TV | LOCATION / WEATHER | |
Buffalo | @ Los Angeles | 6:20 AM | NBC | SoFi Stadium, Inglewood, CA |
Sunday, September 11, 2022
MATCHUP | TIME | TV | LOCATION / WEATHER | |
New Orleans | @ Atlanta | 11:00 PM | FOX | Mercedes-Benz Stadium, Atlanta, GA |
San Francisco | @ Chicago | 11:00 PM | FOX | Soldier Field, Chicago, IL |
Pittsburgh | @ Cincinnati | 11:00 PM | CBS | Paycor Stadium, Cincinnati, OH |
Philadelphia | @ Detroit | 11:00 PM | FOX | Ford Field, Detroit, MI |
New England | @ Miami | 11:00 PM | CBS | Hard Rock Stadium, Miami Gardens, FL |
Baltimore | @ New York | 11:00 PM | CBS | MetLife Stadium, East Rutherford, NJ |
Jacksonville | @ Washington | 11:00 PM | FOX | FedExField, Landover, MD |
Cleveland | @ Carolina | 11:00 PM | CBS | Bank of America Stadium, Charlotte, NC |
Indianapolis | @ Houston | 11:00 PM | CBS | NRG Stadium, Houston, TX |
New York | @ Tennessee | 2:25 AM | FOX | Nissan Stadium, Nashville, TN |
Green Bay | @ Minnesota | 2:25 AM | FOX | U.S. Bank Stadium, Minneapolis, MN |
Kansas City | @ Arizona | 2:25 AM | CBS | State Farm Stadium, Glendale, AZ |
Las Vegas | @ Los Angeles | 2:25 AM | CBS | SoFi Stadium, Inglewood, CA |
Tampa Bay | @ Dallas | 6:20 AM | NBC | AT&T Stadium, Arlington, TX |
Tuesday, September 13, 2022
MATCHUP | TIME | TV | LOCATION / WEATHER | |
Denver | @ Seattle | 6:15 AM | ESPN and ABC | Lumen Field, Seattle, WA |
Live Stream
The fans can enjoy the show on the NFL Network. If you are looking to watch the NFL week 1 games online and completely free, you can do so on a variety of websites as well. However, many of these sites may require you to view ads in the middle of the game. This can be disruptive and take away from your enjoyment of the NFL experience.
So, you may check the fuboTV to enjoy the 2022 NFL week 1 games.