Retirement hasn’t taken the fight out of Peyton Manning. #LoweRoastpic.twitter.com/0kiKBQmnb2
— Comedy Central (@ComedyCentral) August 29, 2016
Peyton Manning may have been just joking here, but the timing is not the best. Tom Brady is about to serve a four game suspension for Deflategate, so any jokes about deflated balls are not going to be received well by Tom Brady and New England fans.
Peyton Manning had his own controversy to deal wiith after claims of HGH use by Al Jazeera America. Manning met with the NFL and was cleared of any wrong doing, but I would imagine it would be best to stay away from jokes referring to any kind of cheating, especially about a former rival.